A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and fungi
Identifieur interne : 001851 ( Main/Exploration ); précédent : 001850; suivant : 001852A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and fungi
Auteurs : Tarek Hamouda [États-Unis] ; Andrzej Myc [États-Unis] ; Brian Donovan [États-Unis] ; Amy Y. Shih [États-Unis] ; Jon D. Reuter [États-Unis] ; James R. Baker [États-Unis]Source :
- Microbiological Research [ 0944-5013 ] ; 2001.
English descriptors
- Teeft :
- Adenovirus, Antimicrobial, Antimicrobial nanoemulsions, Assay, Atcc, Bacillus, Bacillus cereus, Bacillus subtilis, Bacterial count, Bactericidal, Bactericidal activity, Biocidal, Candida albicans, Cell growth medium, Different concentrations, Enteric bacilli, Enteric bacteria, Equal volume, Equal volumes, Fungistatic, Fungistatic activity, Gonorrhoeae, Growth rate, Haemophilus influenzae, Hamouda, Herpes, Herpes simplex, Herpes simplex virus, Infection medium, Infectious diseases, Influenza, Microbiol, Murine influenza, Nanoemulsion, Neisseria gonorrhoeae, Novel surfactant nanoemulsion, Ongoing need, Overnight incubation, Recombinant adenovirus, Simplex, Streptococcus pneumoniae, Surfactant, Surfactant nanoemulsion, Time course, Vaccinia, Vaccinia virus, Variable time intervals, Vegetative bacteria, Vibrio cholerae, Viral envelope, Virucidal, Virucidal activity, Virus, Virus pneumonitis.
Abstract
Summary: A novel non-ionic surfactant nanoemulsion designated 8N8 has been tested for its biocidal activity. One percent 8N8 produced effective bactericidal activity against Bacillus cereus, Bacillus subtilis, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus pneumoniae, and Vibrio cholerae in 15 minutes. In contrast, most enteric Gram-negative bacteria were resistant to 8N8. One percent 8N8 was also virucidal within 15 minutes for all tested enveloped viruses, including Herpes simplex type 1, influenza A and vaccinia viruses. One percent 8N8 also demonstrated fungistatic activity on Candida albicans. The rapid and non-specific inactivation of vegetative bacteria and enveloped viruses, in addition to its fungistatic activity and low toxicity in experimental animals, makes 8N8 a potential candidate for use as a topical biocidal agent.
Url:
DOI: 10.1078/0944-5013-00069
Affiliations:
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Shih</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Allergy, Department of Internal Medicine, and Center for Biologic Nanotechnology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Reuter, Jon D" sort="Reuter, Jon D" uniqKey="Reuter J" first="Jon D." last="Reuter">Jon D. 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Baker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Division of Allergy, Department of Internal Medicine, and Center for Biologic Nanotechnology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Microbiological Research</title><title level="j" type="abbrev">MICRES</title><idno type="ISSN">0944-5013</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">156</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="7">7</biblScope></imprint><idno type="ISSN">0944-5013</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0944-5013</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenovirus</term><term>Antimicrobial</term><term>Antimicrobial nanoemulsions</term><term>Assay</term><term>Atcc</term><term>Bacillus</term><term>Bacillus cereus</term><term>Bacillus subtilis</term><term>Bacterial count</term><term>Bactericidal</term><term>Bactericidal activity</term><term>Biocidal</term><term>Candida albicans</term><term>Cell growth medium</term><term>Different concentrations</term><term>Enteric bacilli</term><term>Enteric bacteria</term><term>Equal volume</term><term>Equal volumes</term><term>Fungistatic</term><term>Fungistatic activity</term><term>Gonorrhoeae</term><term>Growth rate</term><term>Haemophilus influenzae</term><term>Hamouda</term><term>Herpes</term><term>Herpes simplex</term><term>Herpes simplex virus</term><term>Infection medium</term><term>Infectious diseases</term><term>Influenza</term><term>Microbiol</term><term>Murine influenza</term><term>Nanoemulsion</term><term>Neisseria gonorrhoeae</term><term>Novel surfactant nanoemulsion</term><term>Ongoing need</term><term>Overnight incubation</term><term>Recombinant adenovirus</term><term>Simplex</term><term>Streptococcus pneumoniae</term><term>Surfactant</term><term>Surfactant nanoemulsion</term><term>Time course</term><term>Vaccinia</term><term>Vaccinia virus</term><term>Variable time intervals</term><term>Vegetative bacteria</term><term>Vibrio cholerae</term><term>Viral envelope</term><term>Virucidal</term><term>Virucidal activity</term><term>Virus</term><term>Virus pneumonitis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary: A novel non-ionic surfactant nanoemulsion designated 8N8 has been tested for its biocidal activity. One percent 8N8 produced effective bactericidal activity against Bacillus cereus, Bacillus subtilis, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus pneumoniae, and Vibrio cholerae in 15 minutes. In contrast, most enteric Gram-negative bacteria were resistant to 8N8. One percent 8N8 was also virucidal within 15 minutes for all tested enveloped viruses, including Herpes simplex type 1, influenza A and vaccinia viruses. One percent 8N8 also demonstrated fungistatic activity on Candida albicans. The rapid and non-specific inactivation of vegetative bacteria and enveloped viruses, in addition to its fungistatic activity and low toxicity in experimental animals, makes 8N8 a potential candidate for use as a topical biocidal agent.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Hamouda, Tarek" sort="Hamouda, Tarek" uniqKey="Hamouda T" first="Tarek" last="Hamouda">Tarek Hamouda</name></region><name sortKey="Baker, James R" sort="Baker, James R" uniqKey="Baker J" first="James R." last="Baker">James R. Baker</name><name sortKey="Baker, James R" sort="Baker, James R" uniqKey="Baker J" first="James R." last="Baker">James R. Baker</name><name sortKey="Donovan, Brian" sort="Donovan, Brian" uniqKey="Donovan B" first="Brian" last="Donovan">Brian Donovan</name><name sortKey="Myc, Andrzej" sort="Myc, Andrzej" uniqKey="Myc A" first="Andrzej" last="Myc">Andrzej Myc</name><name sortKey="Reuter, Jon D" sort="Reuter, Jon D" uniqKey="Reuter J" first="Jon D." last="Reuter">Jon D. Reuter</name><name sortKey="Reuter, Jon D" sort="Reuter, Jon D" uniqKey="Reuter J" first="Jon D." last="Reuter">Jon D. Reuter</name><name sortKey="Shih, Amy Y" sort="Shih, Amy Y" uniqKey="Shih A" first="Amy Y." last="Shih">Amy Y. Shih</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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